Natural Way to Treat Nasal Polyps


Chronic rhinosinusitis with nasal polyposis (CRSwNP) frequently coexists with asthma. This analysis examined improvements inquality of life (QoL) in patients with Nasal Polyps and comorbid asthmatreated with this natural way  versus placebo.

Analyses were conducted in a pre-specified subgroup ofpatients with corticosteroid-refractory Nasal Polyps and comorbid asthma enrolled in phase III, placebo-controlled, 24-week, trials of omalizumab,P OLYP1 (n574) and POLYP2 (n577). The odds of achieving minimallyimportant difference (MID;>_0.5 points) in the Asthma Quality of Life  (AQLQ) at Week 24 and mean change from baseline toWeek 24 in the sino-nasal outcome test

At baseline, mean  Quality of Life scores were 4.6 (1.4) and 5.1(1.3) and mean SNOT-22 scores were 62.2 (18.0) and 61.7 (17.3) inpatients with asthma from POLYP1 and POLYP2. Omalizumab-treatedpatients were significantly more likely than placebo-treated patients toachieve MID in AQLQ in each study. In the pooled population, the oddsratio for achieved MID improvement in AQLQ was 3.9 (95% CI: 1.5, 9.7;P50.0043). Among patients with comorbid asthma, the SNOT-22improvement from baseline to Week 24 was significantly greater in oma-lizumab than placebo groups in each study. In the pooled population ofasthma patients, mean improvement from baseline to Week 24 in SNOT-22 was 23.2 vs -8.4 for omalizumab vs placebo (P<0.0001). Adverseevents were generally similar between study arms.

Among Nasal Polyps patients and comorbid asthma, this natural way  significantly improved quality of life measured by SNOT-22 andodds of improving AQLQ

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Staphylococcus aureus is a frequent colonizer of the upper airways in chronic rhinosinusitis with nasal polyps, but also resides intramucosally; it has been shown that secreted staphylococcal proteins such as enterotoxins and serine proteases induce the release of cytokines such as IL-5.  Recent study have analyzed nasal polyp tissue freshly obtained during routine surgery, which did or did not contain cultivatable S. aureus, to study spontaneous IL-5 production by nasal polyp tissue over 24 and 72 h in tissue culture. In S. aureus-positive samples was interfered by killing the bacteria using antibiotics or S. aureus specific intravenous staphylococcal phages (ISP), active or heat-inactivated This study also demonstrate that cultivatable S. aureus may be found in type-2 inflamed nasal polyps; the pathogen is replicating within 24 h and secretes proteins, including enterotoxins and serine proteases. The presence of S. aureus was associated with a significantly higher release of IL-5. Ki
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