Is Glucocorticoid the Best way to Treat Nasal Polyps ?


There is little evidence on the efficacy of glucocorticoid transnasal nebulization therapy in patients with eosinophilic chronic rhinosinusitis with nasal polyps.

In recent study,  scientists sought to evaluate the immunologic andremodeling effects of budesonide transnasal nebulization inpatients with eosinophilic Nasal Polyps Sixty patients with eosinophilic Nasal Polyps wererandomized to receive budesonide or placebo treatment for14 days by means of transnasal nebulization in a double-blindmanner. Endoscopic polyp size scores (maximum56 points, Kennedy score) and visual analog scale scores for nasals ymptoms were assessed before and after treatment. Similarly,polyp samples were evaluated for inflammatory cytokines,matrix metallo proteinases (MMPs), and tissue inhibitors ofmetalloproteinases (TIMPs) by using an immuno assay;collagen by using histochemistry; eosinophils by using hematoxylin and eosin stain; and T-cell subsets by using flow cytometry.

In conclustion,  Short-term budesonide transnasal nebulization isan effective and safe treatment option in patients witheosinophilic Nasal Polyps , achieving clinical improvement byregulating remodeling, cytokine expression, and T-cell subsetdistribution. But it's not natural way to get rid of nasal polyps.

Read more : Natural Way to Treat Nasal Polyps at Home

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Staphylococcus aureus is a frequent colonizer of the upper airways in chronic rhinosinusitis with nasal polyps, but also resides intramucosally; it has been shown that secreted staphylococcal proteins such as enterotoxins and serine proteases induce the release of cytokines such as IL-5.  Recent study have analyzed nasal polyp tissue freshly obtained during routine surgery, which did or did not contain cultivatable S. aureus, to study spontaneous IL-5 production by nasal polyp tissue over 24 and 72 h in tissue culture. In S. aureus-positive samples was interfered by killing the bacteria using antibiotics or S. aureus specific intravenous staphylococcal phages (ISP), active or heat-inactivated This study also demonstrate that cultivatable S. aureus may be found in type-2 inflamed nasal polyps; the pathogen is replicating within 24 h and secretes proteins, including enterotoxins and serine proteases. The presence of S. aureus was associated with a significantly higher release of IL-5. Ki
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